Dimethylformamide → 4-{3-[5-Chloro-4-(4-cyclopropylcarbamoylbenzo[b]thiophen-2-yl)-pyrimidin-2-ylamino]-propyl}-piperidine-1-carboxylic acid amide

HRID 85804Notes

Reaction equation

HRID 85804 reaction equation
[CH3:1][Si:2]([CH3:3])([CH3:4])[N:5]=[C:6]=[O:7].[CH3:45][CH2:46][O:47][C:48](=[O:49])[CH3:50].[CH:8]1([NH:11][C:12](=[O:13])[c:14]2[cH:15][cH:16][cH:17][c:18]3[s:19][c:20](-[c:23]4[n:24][c:25]([NH:30][CH2:31][CH2:32][CH2:33][CH:34]5[CH2:35][CH2:36][NH:37][CH2:38][CH2:39]5)[n:26][cH:27][c:28]4[Cl:29])[cH:21][c:22]23)[CH2:9][CH2:10]1.[O:40]=[CH:41][N:42]([CH3:43])[CH3:44]>>[NH2:5][C:6](=[O:7])[N:37]1[CH2:36][CH2:35][CH:34]([CH2:33][CH2:32][CH2:31][NH:30][c:25]2[n:24][c:23](-[c:20]3[s:19][c:18]4[cH:17][cH:16][cH:15][c:14]([C:12]([NH:11][CH:8]5[CH2:9][CH2:10]5)=[O:13])[c:22]4[cH:21]3)[c:28]([Cl:29])[cH:27][n:26]2)[CH2:39][CH2:38]1

Participants

5

Reactant 4

HCID 6228DimethylformamideHCID 8857Ethyl AcetateHCID 70696Trimethylsilyl isocyanateHCID 688569192-[5-Chloro-2-(3-piperidin-4-yl-propylamino)-pyrimidin-4-yl]-benzo[b]thiophene-4-carboxylic acid cyclopropylamide

Product 1

HCID 688588614-{3-[5-Chloro-4-(4-cyclopropylcarbamoylbenzo[b]thiophen-2-yl)-pyrimidin-2-ylamino]-propyl}-piperidine-1-carboxylic acid amide

Sources & evidence

ORD record
ord-501a7404b30d4ce69037a7d56f70d567
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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