4-Bromophenol → 1-Bromo-4-(methoxymethoxy)benzene

HRID 858265Notes

Reaction equation

HRID 858265 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.[CH3:9][O:10][CH2:11]Cl>>[CH3:9][O:10][CH2:11][O:8][C:5]1[CH:6]=[CH:7][C:2]([Br:1])=[CH:3][CH:4]=1

Participants

3

Reactant 2

HCID 78084-BromophenolHCID 7864Chloromethyl Methyl Ether

Product 1

HCID 104659191-Bromo-4-(methoxymethoxy)benzeneYield 104.2%

Procedure

In a manner similar to that of Example 7(a), by reaction of 48.84 g (282.3 mmol) of 4-bromophenol with 25.0 ml (310.5 mmol) of chloromethyl methyl ether, 63.85 g (100%) of the expected product are obtained in the form of a beige-coloured oil.

Sources & evidence

ORD record
ord-4d470c1c4e2b45d9ac8c28245222b495
Source dataset
uspto-grants-2006_12
Patent number
US07148245B2

Reaction notes

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