Carbon Tetrachloride → HCID 68845740, compound

HRID 858303Notes

Reaction equation

HRID 858303 reaction equation
[C:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6](=[C:13](O)[C:14]2[CH:18]=[C:17]([CH3:19])[O:16][N:15]=2)[C:5]1=[O:21])(=[O:3])[CH3:2].C(Cl)(Cl)(Cl)[Cl:23].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>C1COCC1>[C:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6](=[C:13]([Cl:23])[C:14]2[CH:18]=[C:17]([CH3:19])[O:16][N:15]=2)[C:5]1=[O:21])(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 5943Carbon TetrachlorideHCID 11776TriphenylphosphineHCID 178473972HCID 178473972, compound

Product 1

HCID 68845740HCID 68845740, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

3.00 g of 1-acetyl-3-[1-hydroxy-1-(5-methyl-3-isoxazolyl)methylene]-2-indolinone, 5.09 ml carbon tetrachloride and 5.54 g triphenylphosphine are refluxed in 100 ml of THF for 8 hours. The residue obtained after the solvent has been distilled off is purified by chromatography on silica gel (eluant: petroleum ether/ethyl acetate=9:1).

Workup

  1. customThe residue obtained after the solvent
  2. distillationhas been distilled off
  3. customis purified by chromatography on silica gel (eluant: petroleum ether/ethyl acetate=9:1)

Sources & evidence

ORD record
ord-57b9d093116b4c9b99a7e64f89c6ce38
Source dataset
uspto-grants-2006_12
Patent number
US07148249B2

Reaction notes

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