反应详情

5,6 Dimethoxy indanone (100 grams), Pyridine-4-carboxaldehyde (78.0 grams) and p-toluene sulfonic acid (138.4 grams) were suspended in toluene (1250 ml) and heated to reflux using water separator for 6 hours. The resulting mass was cooled to 25–40° C. and the solid was filtered off under suction. Further the wet solid was suspended in aqueous 10% sodium carbonate solution (1200 ml) and stirred for 30–60 minutes. The resulting pale yellow precipitate solid was filtered off under suction, washed with water (1000 ml) and dried at a temperature of 80° C. to afford 5,6 Dimethoxy-2-(pyridin-4yl)-methylene-indan-1one (Weight: 140 grams, 95.8%).

1. temperatureheated
2. temperatureto reflux
3. customseparator for 6 hours
4. temperatureThe resulting mass was cooled to 25–40° C.
5. filtrationthe solid was filtered off under suction
6. filtrationThe resulting pale yellow precipitate solid was filtered off under suction
7. washwashed with water (1000 ml)
8. customdried at a temperature of 80° C.