反应详情

温度

110 °C

100 mg (0.26 mmol) of 1-cyclopropyl-2-{2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]-pyridin-3-yl]-5-pyrimidinyl}ethanone (example XXVI, step 1) are added to a solution of 123 mg (1.03 mmol) of N-(dimethoxymethyl)-N,N-dimethylamine in 1 ml of DMF. The reaction mixture is stirred at 110° C. for 2 hours and then poured into distilled water. The precipitated solid is filtered off, washed with distilled water and dried. 93 mg (64% of theory) of the product are obtained and are directly reacted further without further purification.

1. additionpoured
2. distillationinto distilled water
3. filtrationThe precipitated solid is filtered off
4. washwashed with distilled water
5. customdried
6. custom93 mg (64% of theory) of the product are obtained
7. customare directly reacted further without further purification