Lithium Hydroxide → HCID 11019077, compound

HRID 858560Notes

Reaction equation

HRID 858560 reaction equation
[Li+].[OH-].C([O:5][C:6](=[O:15])[CH2:7][CH2:8][C:9]1[CH2:14][CH2:13][CH2:12][CH2:11][CH:10]=1)C>C1COCC1.CO>[C:9]1([CH2:8][CH2:7][C:6]([OH:15])=[O:5])[CH2:14][CH2:13][CH2:12][CH2:11][CH:10]=1

Participants

5

Reactant 2

HCID 3939Lithium HydroxideHCID 107261201-Cyclohexene-1-propanoic acid, ethyl ester

Product 1

HCID 11019077HCID 11019077, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

2N LiOH (3.5 mL) was added to a solution of 3-Cyclohex-1-enyl-propionic acid ethyl ester (0.6 g, 3.4 mmol, from Step 1) dissolved in THF (12 mL) and MeOH (3 mL). The mixture was stirred for 2 h under N2 and then partitioned between 1N HCl and EtOAc. The organic layer was washed with brine, dried over Na2SO4 and concentrated to a clear oil.

Workup

  1. custompartitioned between 1N HCl and EtOAc
  2. washThe organic layer was washed with brine
  3. dry with materialdried over Na2SO4
  4. concentrationconcentrated to a clear oil

Sources & evidence

ORD record
ord-9a52dd10241240ae8c8a9294b19ccf9c
Source dataset
uspto-grants-2006_12
Patent number
US07148226B2

Reaction notes

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