反应详情

Benzyl bromide (12.9 mL, 108 mmol), K2CO3 (15.0 g, 109 mmol) and the 3-(4-hydroxyphenyl)propionic acid methyl ester from Step 1 above were combined in acetone (300 mL) and refluxed 40 h. The crude reaction mixture was filtered and the cake washed with acetone (2×100 mL). The filtrate was evaporated and the residue was triturated with MeOH (50 mL, 6 mL, 4 mL) to provide the product as a solid which was used without further purification.

1. temperaturerefluxed 40 h
2. customThe crude reaction mixture
3. filtrationwas filtered
4. washthe cake washed with acetone (2×100 mL)
5. customThe filtrate was evaporated
6. customthe residue was triturated with MeOH (50 mL, 6 mL, 4 mL)