Sodium Hydroxide → HCID 69588346, compound

HRID 859147Notes

Reaction equation

HRID 859147 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[N:14]2[N:15]=[C:16]([CH3:23])[C:17](C(OCC)=O)=[C:13]2[CH:12]=[CH:11][C:10]=1[CH3:24].[OH-].[Na+].C([O-])(O)=O.[Na+]>OS(O)(=O)=O>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[N:14]2[N:15]=[C:16]([CH3:23])[CH:17]=[C:13]2[CH:12]=[CH:11][C:10]=1[CH3:24]

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 516892Sodium BicarbonateHCID 69588313HCID 69588313, compound

Product 1

HCID 69588346HCID 69588346, compound

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Conditions

Temperature
150 °C

Procedure

Ethyl 7-(2,4-dichlorophenyl)-2,6-dimethylpyrazolo[1,5-a]pyridine-3-carboxylate (930 mg, 2.56 mmol) was treated with 50% H2SO4 (10 mL) and heated to 150° C. for 2.5 hours. The reaction was cooled in an ice bath and treated with 4N NaOH (19 mL) and NaHCO3 (4.80 g).

Workup

  1. temperatureThe reaction was cooled in an ice bath

Sources & evidence

ORD record
ord-d3b5936ccae748d182f760113b31d778
Source dataset
uspto-grants-2006_12
Patent number
US07151109B2

Reaction notes

Loading…