Trifluoroacetic acid → HCID 22224824, compound

HRID 859508Notes

Reaction equation

HRID 859508 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([O:20][CH3:21])[CH:15]=2)=[CH:10][C:9]=1[NH:22][C:23](=[O:35])[CH2:24][C:25]([C:27]1[CH:32]=[CH:31][CH:30]=[C:29]([C:33]#[N:34])[CH:28]=1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:21][O:20][C:16]1[CH:15]=[C:14]([C:11]2[CH:12]=[CH:13][C:8]3[N:7]=[C:25]([C:27]4[CH:28]=[C:29]([CH:30]=[CH:31][CH:32]=4)[C:33]#[N:34])[CH2:24][C:23](=[O:35])[NH:22][C:9]=3[CH:10]=2)[CH:19]=[CH:18][CH:17]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86588010HCID 86588010, compound

Product 1

HCID 22224824HCID 22224824, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Prepared from {3-[3-(3-cyano-phenyl)-3-oxo-propionylamino]-3′-methoxy-biphenyl-4-yl}-carbamic acid tert.-butyl ester (Example K21) by treatment with TFA in CH2Cl2 according to the general procedure M. Obtained as a light yellow powder (118 mg).

Sources & evidence

ORD record
ord-dcaa7768058447968563b9f4520571bb
Source dataset
uspto-grants-2006_12
Patent number
US07151098B2

Reaction notes

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