Trimethylsilylacetylene → HCID 22224724, compound

HRID 859591Notes

Reaction equation

HRID 859591 reaction equation
I[C:2]1[CH:3]=[C:4]([C:8]2[CH2:14][C:13](=[O:15])[NH:12][C:11]3[CH:16]=[C:17]([C:20]#[C:21][C:22]4[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=4)[CH:18]=[CH:19][C:10]=3[N:9]=2)[CH:5]=[CH:6][CH:7]=1.[CH3:28][Si:29]([C:32]#[CH:33])([CH3:31])[CH3:30]>>[C:22]1([C:21]#[C:20][C:17]2[CH:18]=[CH:19][C:10]3[N:9]=[C:8]([C:4]4[CH:5]=[CH:6][CH:7]=[C:2]([C:33]#[C:32][Si:29]([CH3:31])([CH3:30])[CH3:28])[CH:3]=4)[CH2:14][C:13](=[O:15])[NH:12][C:11]=3[CH:16]=2)[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

Participants

3

Reactant 2

HCID 66111TrimethylsilylacetyleneHCID 22224695(E)-4-(3-iodophenyl)-8-(2-phenylethynyl)-1H-benzo[b][1,4]diazepin-2(3H)-one

Product 1

HCID 22224724HCID 22224724, compoundYield 47.2%

Procedure

Prepared from 4-(3-iodophenyl)-8-phenylethynyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one (Example 11) (231 mg, 0.5 mmol) and trimethylsilylacetylene (0.4 mL, 1.0 mmol) according to the general procedure F. Obtained as a light brown solid (102 mg).

Sources & evidence

ORD record
ord-be745568c99f47449d393a83a6400267
Source dataset
uspto-grants-2006_12
Patent number
US07151098B2

Reaction notes

Loading…