Dimethylformamide → HCID 69120508, compound

HRID 859843Notes

Reaction equation

HRID 859843 reaction equation
[CH:1]1([NH:4][CH2:5][C:6]2[C:7](OC)=[CH:8][C:9]([F:13])=[C:10]([F:12])[CH:11]=2)[CH2:3][CH2:2]1.[H-].[Na+].[CH3:18]I.CN(C)[CH:22]=[O:23]>>[CH:1]1([NH:4][CH2:5][CH2:6][C:7]2[C:18]([O:23][CH3:22])=[CH:11][C:10]([F:12])=[C:9]([F:13])[CH:8]=2)[CH2:2][CH2:3]1

Participants

5

Reactant 4

HCID 6228DimethylformamideHCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 69120506HCID 69120506, compound

Product 1

HCID 69120508HCID 69120508, compound

Conditions

Temperature
40 °C

Procedure

2 g of cyclopropyl(4,5-difluoro-2-anisyl)amine and 0.48 g of sodium hydride are stirred in 10 ml of dimethylformamide for 20 min at ambient temperature, 1.25 ml of methyl iodide are subsequently added and the mixture is additionally stirred for 20 h at 40° C. After filtering and evaporating, the reaction mixture is taken up in diethyl ether and the organic phase is washed with water, dried with magnesium sulfate and evaporated to dryness. Cyclopropyl-(4,5-difluoro-2-anisyl)methylamine is thus obtained as a yellow oil.

Workup

  1. filtrationAfter filtering
  2. customevaporating
  3. washthe organic phase is washed with water
  4. dry with materialdried with magnesium sulfate
  5. customevaporated to dryness

Sources & evidence

ORD record
ord-94e3a060cbb646f9b81879ad485b8477
Source dataset
uspto-grants-2006_12
Patent number
US07153814B2

Reaction notes

Loading…