反应详情

4-Trifluoromethylphenyl hydrazine (4.1 g, 23 mmol) was gradually added to a solution of concentrated hydrochloric acid (5 ml) in water (120 ml). 40% aqueous solution (4.3 g, 23 mmol) of glyoxylic acid was gradually added, and stirred at room temperature for 5 hours. After leaving it overnight, the mixture was extracted with ethyl acetate. The organic phase was washed with a saturated brine, and dried on anhydrous sodium sulfate. The solvent was distilled off, and the resulting crystals were washed with hexane and a little amount of ethyl acetate to obtain (4-trifluoromethylphenyl hydrazono) acetic acid (4.7 g, 20 mmol, 88%).

1. customAfter leaving it overnight
2. extractionthe mixture was extracted with ethyl acetate
3. washThe organic phase was washed with a saturated brine
4. dry with materialdried on anhydrous sodium sulfate
5. distillationThe solvent was distilled off
6. washthe resulting crystals were washed with hexane