Phosphorus oxychloride → HCID 17954522, compound

HRID 859992Notes

Reaction equation

HRID 859992 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[C:8](O)[CH:7]=[C:6]2[NH:14][C:15]1[CH:20]=[CH:19][C:18]([Cl:21])=[C:17]([Cl:22])[CH:16]=1.O=P(Cl)(Cl)[Cl:25]>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[C:8]([Cl:25])[CH:7]=[C:6]2[NH:14][C:15]1[CH:20]=[CH:19][C:18]([Cl:21])=[C:17]([Cl:22])[CH:16]=1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 178488024HCID 178488024, compound

Product 1

HCID 17954522HCID 17954522, compoundYield 61%

Procedure

Prepared using general procedure 3; 6-Methoxy-2-hydroxy-4-(3,4-dichlorophenyl)aminoquinoline (1.05 g, 3.13 mmol) and 26 mL of POCl3 were heated to 120° C. for 4 h. Isolation afforded 0.685 g of material (1.94 mmol, 61%).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-248ecc8b5c6f428aab0379b88cb0256c
Source dataset
uspto-grants-2006_12
Patent number
US07153865B2

Reaction notes

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