Phosphorus oxychloride → 2-chloro-6-(trifluoroMethoxy) quinoline

HRID 860019Notes

Reaction equation

[F:1][C:2]([F:16])([F:15])[O:3][C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[NH:10][C:9](=O)[CH:8]=[CH:7]2.P(Cl)(Cl)([Cl:19])=O>>[Cl:19][C:9]1[CH:8]=[CH:7][C:6]2[C:11](=[CH:12][CH:13]=[C:4]([O:3][C:2]([F:16])([F:15])[F:1])[CH:5]=2)[N:10]=1

Participants

Reactant 2

HCID 24813Phosphorus oxychloride

HCID 58765320HCID 58765320, compound

Product 1

HCID 587653242-chloro-6-(trifluoroMethoxy) quinoline

Procedure

The title compound may be prepared in a manner analogous to Example 3, Step C, from the 6-trifluoromethoxy-1H-quinolin-2-one of Step C, and phosphorous oxychloride.

Sources & evidence

ORD record: ord-322ea5a0ae684df5b2a7f08ec77f8e32
Source dataset: uspto-grants-2006_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07153849B2

Reaction notes

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