Hydrochloric Acid → 2-Amino-3-nitrobenzoic acid

HRID 860030Notes

Reaction equation

HRID 860030 reaction equation
Cl[C:2]1[C:10]([N+:11]([O-:13])=[O:12])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].Cl.[OH-].[NH4+:16]>O>[NH2:16][C:2]1[C:10]([N+:11]([O-:13])=[O:12])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14923Ammonium HydroxideHCID 198702-Chloro-3-nitrobenzoic acid

Product 1

HCID 2196332-Amino-3-nitrobenzoic acid

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
120 °C

Procedure

2-Chloro-3-nitrobenzoic acid (20.6 g, 0.24 mol) was dissolved in ammonium hydroxide solution (120 mL) and the reaction mixture stirred at 120° C. in a sealed vessel for 7 hours. The reaction mixture was diluted with water (250 mL) and acidified to pH 2 with hydrochloric acid. The precipitate formed was filtered off and dried in vacuo to yield the title product, 15.0 g (80%).

Workup

  1. customThe precipitate formed
  2. filtrationwas filtered off
  3. customdried in vacuo

Sources & evidence

ORD record
ord-9dd21a4d1abf465087b1d50fe2c2ff35
Source dataset
uspto-grants-2006_12
Patent number
US07153870B2

Reaction notes

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