反应详情

HCl was bubbled into a n-butanol solution (200 mL) of pent-4-ynoic acid 6-3 (10 g, 102 mmol) for ten minutes. The solution was stirred overnight at room temperature. The solvent was removed in vacuo providing the crude ester 6-4 as a yellow liquid in quantitative yield.

1. customThe solvent was removed in vacuo