Hydrochloric Acid → Pent-4-ynoic acid butyl ester

HRID 860052Notes

Reaction equation

HRID 860052 reaction equation
Cl.[C:2]([OH:8])(=[O:7])[CH2:3][CH2:4][C:5]#[CH:6]>C(O)CCC>[CH2:2]([O:7][C:2](=[O:8])[CH2:3][CH2:4][C:5]#[CH:6])[CH2:3][CH2:4][CH3:5]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 224644-Pentynoic acid

Product 1

HCID 23435506Pent-4-ynoic acid butyl ester

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

HCl was bubbled into a n-butanol solution (200 mL) of pent-4-ynoic acid 6-3 (10 g, 102 mmol) for ten minutes. The solution was stirred overnight at room temperature. The solvent was removed in vacuo providing the crude ester 6-4 as a yellow liquid in quantitative yield.

Workup

  1. customThe solvent was removed in vacuo

Sources & evidence

ORD record
ord-71db8738a7f24b4bb6e443eca90e312d
Source dataset
uspto-grants-2006_12
Patent number
US07153862B2

Reaction notes

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