Acetyl chloride → HCID 178418832, compound

HRID 860126Notes

Reaction equation

HRID 860126 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([Cl:8])[CH:5]=[C:4]([NH2:9])[N:3]=1.[CH:10]1([N+:16]#[C-:17])[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]1.[N:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[CH:24]=O.[C:26](Cl)(=[O:28])[CH3:27]>Cl(O)(=O)(=O)=O>[Cl-:8].[C:26]([N+:1]1[C:24]([C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][N:18]=2)=[C:17]([NH:16][CH:10]2[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]2)[N:3]2[C:4]([NH2:9])=[CH:5][C:6]([Cl:8])=[N:7][C:2]=12)(=[O:28])[CH3:27]

Participants

6

Reactant 4

HCID 6367Acetyl chlorideHCID 142732-PyridinecarboxaldehydeHCID 674322,4-Diamino-6-chloropyrimidineHCID 79129Cyclohexyl isocyanide

Product 1

HCID 178418832HCID 178418832, compound

Reagents, catalysts & solvents 1

HCID 24247Perchloric AcidSolvent

Procedure

Example 20 was carried out in accordance with the general directions for synthesis in process step a) from 1.0 ml (0.1 mmol) 2,6-diamino-4-chloro-pyrimidine (0.1 M, DCM), 0.575 ml (0.115 mmol) cyclohexylisonitrile solution (0.2 M, DCM), 0.500 ml (0.15 mmol) pyridine-2-carbaldehyde solution (0.3 M, DCM) and 10 μl perchloric acid (w=20%) and in process step c) and d) by reacting the resultant reaction product with 0.4 mmol acetylchloride.

Sources & evidence

ORD record
ord-39629a9e5f1f4130883a2c8192d46a72
Source dataset
uspto-grants-2006_12
Patent number
US07153873B2

Reaction notes

Loading…