Acetaldehyde → HCID 178473832, compound

HRID 860134Notes

Reaction equation

HRID 860134 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][N:3]=1.[CH3:11][C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([CH3:18])[C:13]=1[N+:19]#[C-:20].[CH:21](=[O:23])[CH3:22].[C:24]([Cl:27])(=O)[CH3:25]>Cl(O)(=O)(=O)=O>[Cl-:27].[C:21]([N+:1]1[C:24]([CH3:25])=[C:20]([NH:19][C:13]2[C:14]([CH3:18])=[CH:15][CH:16]=[CH:17][C:12]=2[CH3:11])[N:3]2[CH:4]=[C:5]([N+:8]([O-:10])=[O:9])[CH:6]=[CH:7][C:2]=12)(=[O:23])[CH3:22]

Participants

6

Reactant 4

HCID 177AcetaldehydeHCID 6367Acetyl chlorideHCID 760092,6-Dimethylphenyl isocyanideHCID 778882-Amino-5-nitropyridine

Product 1

HCID 178473832HCID 178473832, compound

Reagents, catalysts & solvents 1

HCID 24247Perchloric AcidSolvent

Procedure

Example 30 was carried out in accordance with the general directions for synthesis in process step a) from 1.0 ml (0.1 mmol) 2-amino-5-nitropyridine (0.1 M, DCM), 0.575 ml (0.115 mmol) 2,6-dimethylphenylisocyanide solution (0.2 M, DCM), 0.500 ml (0.15 mmol) acetaldehyde solution (0.3 M, DCM) and 10 μl perchloric acid (w=20%) and in process step c) and d) by reacting the resultant reaction product with 0.4 mmol acetylchloride.

Sources & evidence

ORD record
ord-a3c46494203d4aa792a815effaa31996
Source dataset
uspto-grants-2006_12
Patent number
US07153873B2

Reaction notes

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