Hydrochloric Acid → HCID 68804119, compound

HRID 860455Notes

Reaction equation

HRID 860455 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]([C:9]2[C:10]3[N:11]([C:28]([CH2:31][CH3:32])=[CH:29][CH:30]=3)[N:12]=[C:13]([CH3:27])[C:14]=2[CH2:15][CH2:16][CH2:17][CH2:18][NH:19]C(=O)OC(C)(C)C)[CH:6]=[CH:7][CH:8]=1)#[N:2].[ClH:33]>C(OCC)(=O)C>[ClH:33].[NH2:19][CH2:18][CH2:17][CH2:16][CH2:15][C:14]1[C:13]([CH3:27])=[N:12][N:11]2[C:28]([CH2:31][CH3:32])=[CH:29][CH:30]=[C:10]2[C:9]=1[C:5]1[CH:4]=[C:3]([CH:8]=[CH:7][CH:6]=1)[C:1]#[N:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68805055HCID 68805055, compound

Product 1

HCID 68804119HCID 68804119, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To tert-butyl 4-[4-(3-cyanophenyl)-7-ethyl-2-methylpyrrolo[1,2-b]pyridazin-3-yl]butylcarbamate (25 mg) was added 4N hydrogen chloride in ethyl acetate (1 mL) at ambient temperature. After 1 hour, the mixture was evaporated in vacuo. The residue was triturated with isopropyl ether to give 3-[3-(4-aminobutyl)-7-ethyl-2-methylpyrrolo[1,2-b]pyridazin-4-yl]benzonitrile hydrochloride as dark green amorphous (18 mg)

Workup

  1. customthe mixture was evaporated in vacuo
  2. customThe residue was triturated with isopropyl ether

Sources & evidence

ORD record
ord-45f30ff3a9bb4fe880e6aaa5cf5e9922
Source dataset
uspto-grants-2006_12
Patent number
US07153854B2

Reaction notes

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