HCID 57481373, compound → 7-Ethoxy-2-[(5-methyl-3-isoxazolyl)carbonyl]-7-oxoheptanoic acid

HRID 860499Notes

Reaction equation

HRID 860499 reaction equation
[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]([CH:9]([CH2:17][CH2:18][CH2:19][CH2:20][C:21]([O:23][CH2:24][CH3:25])=[O:22])[C:10]([O:12]C(C)(C)C)=[O:11])=[O:8])[CH:3]=1>FC(F)(F)C(O)=O>[CH2:24]([O:23][C:21](=[O:22])[CH2:20][CH2:19][CH2:18][CH2:17][CH:9]([C:7]([C:4]1[CH:3]=[C:2]([CH3:1])[O:6][N:5]=1)=[O:8])[C:10]([OH:12])=[O:11])[CH3:25]

Participants

3

Reactant 1

HCID 57481373HCID 57481373, compound

Product 1

HCID 574445857-Ethoxy-2-[(5-methyl-3-isoxazolyl)carbonyl]-7-oxoheptanoic acidYield 100%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of 1-tert-butyl 7-ethyl 2-[(5-methyl-3-isoxazolyl)carbonyl]heptanedioate (126 mg) in trifluoroacetic acid (1 mL) was stirred for 1.5 hour at room temperature. The volatile was evaporated off, and azeotroped with toluene to give 7-ethoxy-2-[(5-methyl-3-isoxazolyl)carbonyl]-7-oxoheptanoic acid as a pale orange oil (106 mg).

Workup

  1. customThe volatile was evaporated off
  2. customazeotroped with toluene

Sources & evidence

ORD record
ord-08c951ad0e55467790e9bc2a4a8d87be
Source dataset
uspto-grants-2006_12
Patent number
US07153854B2

Reaction notes

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