HCID 10173874, compound → HCID 58765845, compound

HRID 860674Notes

Reaction equation

HRID 860674 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([O:8][CH:9]([C:13]2[O:17][C:16]([C:18]3[CH:23]=[CH:22][C:21]([C:24]([F:27])([F:26])[F:25])=[CH:20][CH:19]=3)=[N:15][C:14]=2[CH3:28])[CH2:10][CH:11]=[CH2:12])[CH:5]=[CH:4][C:3]=1[CH2:29][CH2:30][C:31]([OH:33])=[O:32]>[Pd].O1CCCC1>[CH3:1][C:2]1[CH:7]=[C:6]([O:8][CH:9]([C:13]2[O:17][C:16]([C:18]3[CH:23]=[CH:22][C:21]([C:24]([F:27])([F:26])[F:25])=[CH:20][CH:19]=3)=[N:15][C:14]=2[CH3:28])[CH2:10][CH2:11][CH3:12])[CH:5]=[CH:4][C:3]=1[CH2:29][CH2:30][C:31]([OH:33])=[O:32]

Participants

4

Reactant 1

HCID 10173874HCID 10173874, compound

Product 1

HCID 58765845HCID 58765845, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

3-(2-Methyl-4-{1-[4-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-5-yl]-but-3-enyloxy}-phenyl)-propionic acid (30 mg, 0.065 mmol), 10% Palladium on charcoal (30 mg) and tetrahydrofuran (30 mL) is stirred under a hydrogen balloon 30 min. The solution is filtered over celite and concentrated in vacuo to afford the title compound, 3-(2-Methyl-4-{1-[4-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-5-yl]-butoxy}-phenyl)-propionic acid as a white solid, 30 mg 100%. MS (M++1) 462.

Workup

  1. filtrationThe solution is filtered over celite and
  2. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-2647ec1c17d54937ae69ed7a060bcaf5
Source dataset
uspto-grants-2006_12
Patent number
US07153878B2

Reaction notes

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