反应详情

To a mixture of 2-[5-Ethyl-2-(4-trifluoromethyl-phenyl)-thiazol-4-yl]-propionic acid (0.35 mmol), 3-(4-Amino-2-methyl-phenyl)-propionic acid methyl ester (0.35 mmol), and DMAP (0.01 g, 0.082 mmol) in CH2Cl2 (5 mL) is added EDCI (0.08 g, 0.42 mmol). After stirring for 2 h at RT, the mixture is concentrated. The residue is redissolved in EtOAc, and the organics are washed with 1N HCl (1×), 2N NaOH (2×), water, and brine, and dried with MgSO4. The crude material is purified by flash chromatography to yield the title compound.

1. concentrationthe mixture is concentrated
2. dissolutionThe residue is redissolved in EtOAc
3. washthe organics are washed with 1N HCl (1×), 2N NaOH (2×), water, and brine
4. dry with materialdried with MgSO4
5. customThe crude material is purified by flash chromatography