反应详情

Thebaine (100.0 g dry weight) was dissolved in 85% formic acid (252.3 g). 30% Hydrogen peroxide (43.6 g) was added over a period of about two hours. The mixture was stirred for three hours. Ammonium hydroxide solution was added to the mixture to increase the pH to 8–9. The solid precipitate was filtered and washed with water and ethanol. The solid was dried on the filter and in an oven. The product was 14-hydroxycodeinone (150.52 g damp, 75.32 g dry weight, 75% yield).

1. temperatureto increase the pH to 8–9
2. filtrationThe solid precipitate was filtered
3. washwashed with water and ethanol
4. customThe solid was dried on the
5. filtrationfilter and in an oven