HCID 69373820, compound → HCID 69375686, compound

HRID 861015Notes

Reaction equation

HRID 861015 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]([C:10]2[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[CH:12][CH:11]=2)[OH:9])=[N:6][CH:7]=1>CCOC(C)=O.O=[Mn]=O>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([C:10]2[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[CH:12][CH:11]=2)=[O:9])=[N:6][CH:7]=1

Participants

4

Reactant 1

HCID 69373820HCID 69373820, compound

Product 1

HCID 69375686HCID 69375686, compound

Reagents, catalysts & solvents 2

HCID 14801Manganese dioxideCatalystHCID 8857Ethyl AcetateSolvent

Procedure

To a solution of (5-bromo-pyridin-2-yl)-(4-methoxy-phenyl)-methanol (1.0 eq.) in EtOAc (0.2M) was added MnO2 (3.0 eq.). The mixture was stirred for 1 h, filtered on celite and concentrated to afford the title compound as a white solid.

Workup

  1. filtrationfiltered on celite
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-e140339956ab4924a9d9fa05b001ff55
Source dataset
uspto-grants-2006_12
Patent number
US07153968B2

Reaction notes

Loading…