Hydrochloric Acid → HCID 22097085, compound

HRID 861525Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]([CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18])[C:9](=[O:15])[C:10](OCC)=[O:11])=[C:4]([N+:22]([O-])=O)[CH:3]=1.Cl>C(O)(=O)C.[Fe]>[Cl:1][C:2]1[CH:3]=[C:4]2[C:5](=[CH:6][CH:7]=1)[N:8]([CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18])[C:9](=[O:15])[C:10](=[O:11])[NH:22]2

Participants

Conditions

Temperature: 80 °C

Procedure

101.3 g (0.28 mol) of ethyl N-(4-chloro-2-nitrophenyl)-N-(ethoxycarbonylmethyl)oxamate were dissolved in 11 of acetic acid and heated to 80° C. Then 15.8 g (0.28 mol) of iron powder were added a little at a time. After 2 h, a further 15.8 g (0.28 mol) of iron powder were added. Half an hour later, the mixture was poured into ice-water and acidified with 4M hydrochloric acid. The precipitate was filtered off with suction to yield 75.7 g (95%) of the product.

Workup

filtrationThe precipitate was filtered off with suction

Sources & evidence

ORD record: ord-96031b5c67dd45f5a6985a24d856e873
Source dataset: uspto-grants-1998_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05714489

Reaction notes

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