Phenethylamine → HCID 86750191, compound

HRID 861587Notes

Reaction equation

HRID 861587 reaction equation
[CH2:1]1[C:5]2[C:6]3[C:11]([CH:12]=[CH:13][C:4]=2[S:3][N:2]1[NH:14][C:15]([N:17]1[CH:21]=[CH:20]N=C1)=[S:16])=[CH:10][CH:9]=[CH:8][CH:7]=3.[C:22]1(CCN)[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>CN(C)C=O>[C:22]1([CH2:20][CH2:21][NH:17][C:15]([NH:14][N:2]2[CH2:1][C:5]3[C:6]4[C:11]([CH:12]=[CH:13][C:4]=3[S:3]2)=[CH:10][CH:9]=[CH:8][CH:7]=4)=[S:16])[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

Participants

4

Reactant 2

HCID 1001PhenethylamineHCID 86750190HCID 86750190, compound

Product 1

HCID 86750191HCID 86750191, compoundYield 82.1%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A solution of 1-[(2-naptho[1,2]thiazolyl)-thiocarbamoyl]imidazole (1.6 g, 5 mmol) and 2-phenylethylamine (0.62 g, 5.2 mmol) in N,N-dimethylformamide (20 mL) was stirred at 90° C. for 1 h, the reaction was cooled to room temperature and the solvent removed in vacuo. The residue was crystallized from ethyl acetate to provide 1.5 g (82%) of the titled product:

Workup

  1. customthe solvent removed in vacuo
  2. customThe residue was crystallized from ethyl acetate

Sources & evidence

ORD record
ord-ca377f9bab0243a5ad4aea2bd87f3199
Source dataset
uspto-grants-1998_02
Patent number
US05714503

Reaction notes

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