反应详情

To a solution of 2-(3-nitrobenzoyl)-3-methoxycarbonylpyridine (0.58 g, 2 mmoles) dissolved in ethanol (50 ml), was added hydrazine monohydrate (0.25 ml, 5.1 mmoles). The mixture was refluxed for 4 hours, cooled and ethyl acetate (50 ml) was added. The solid material was collected and dried, yielding 0.58 g of 8-(3-nitrophenyl)-pyrido[2,3-d]pyridazin-5-one, mp 302° C.

1. temperatureThe mixture was refluxed for 4 hours
2. temperaturecooled
3. customThe solid material was collected
4. customdried