Hydrazine hydrate (1:1) → HCID 86752042, compound

HRID 861985Notes

Reaction equation

HRID 861985 reaction equation
O=C1C2C(=CC=CC=2)C(=O)[N:3]1[C:12]1[CH:17]=[C:16]([CH2:18][P:19](=[O:26])([O:23][CH2:24][CH3:25])[O:20][CH2:21][CH3:22])[CH:15]=[CH:14][N:13]=1.O.NN>ClCl>[NH2:3][C:12]1[CH:17]=[C:16]([CH2:18][P:19](=[O:26])([O:20][CH2:21][CH3:22])[O:23][CH2:24][CH3:25])[CH:15]=[CH:14][N:13]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)2×HCID 86752041HCID 86752041, compound

Product 1

HCID 86752042HCID 86752042, compoundYield 96.3%

Reagents, catalysts & solvents 1

HCID 24526ChlorineSolvent

Procedure

The product from Example 15 (1.4 g, 3.7 mmol) was dissolved in CH2 Cl2 (10 mL) and placed in a 25 mL flask. Hydrazine monohydrate (0.187 g, 3.7 mmol) was added to the flask, and the reaction was allowed to stir at room temperature for 2 h. Two additional equivalents of hydrazine monohydrate were added to drive the reaction to completion. Filtering and solvent removal under reduced pressure gave 0.87 g of crude title compound which was used without further purification.

Workup

  1. customplaced in a 25 mL flask
  2. customthe reaction to completion
  3. filtrationFiltering
  4. customsolvent removal under reduced pressure

Sources & evidence

ORD record
ord-2838f63b8b4646de9c2710240ac74d1e
Source dataset
uspto-grants-1998_02
Patent number
US05716964

Reaction notes

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