Methane → HCID 131720463, compound

HRID 861996Notes

Reaction equation

HRID 861996 reaction equation
[CH2:1]([O:3][P:4]([O:20][CH2:21][CH3:22])([C:6]1[N:11]2[CH:12]=[C:13]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[N:14]=[C:10]2[CH:9]=[CH:8][CH:7]=1)=[O:5])[CH3:2].C.P(CC1C2N(C=C(C(O)=O)N=2)C=CC=1)(O)(O)=O.O1CCOCC1.[Cl:47]Cl>CCOCC>[ClH:47].[CH2:1]([O:3][P:4]([O:20][CH2:21][CH3:22])([C:6]1[N:11]2[CH:12]=[C:13]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[N:14]=[C:10]2[CH:9]=[CH:8][CH:7]=1)=[O:5])[CH3:2]

Participants

7

Reactant 5

HCID 297MethaneHCID 24526ChlorineHCID 312751,4-DioxaneHCID 19701110Ethyl 5-(diethoxyphosphinyl)imidazo[1,2-a]pyridine-2-carboxylateHCID 19701381HCID 19701381, compound

Product 1

HCID 131720463HCID 131720463, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

The product from Example 51 (1.6 g, 4.4 mmol) was dissolved in CH2 Cl2 (30 mL), treated with activated charcoal and filtered. To this filtrate was then added 6N HCl in dioxane (0.9 mL, 4.4 mmol) followed by Et2O (100 mL). The precipitated product was filtered, washed with Et2O, and dried in vacuo.

Workup

  1. filtrationfiltered
  2. filtrationThe precipitated product was filtered
  3. washwashed with Et2O
  4. customdried in vacuo

Sources & evidence

ORD record
ord-756be3881f944587ac22bb3e422c4239
Source dataset
uspto-grants-1998_02
Patent number
US05716964

Reaction notes

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