Water → HCID 67661237, compound

HRID 862008Notes

Reaction equation

HRID 862008 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[S:13][C:12]3=[N:14][C:15]([CH3:22])=[C:16]([CH2:17][C:18]([O:20][CH3:21])=[O:19])[N:11]3[N:10]=2)=[CH:5][CH:4]=1.[Br-].[H-].[Na+].O.[CH:27]([O:29][CH3:30])=O>CN(C)C=O>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[S:13][C:12]3=[N:14][C:15]([CH3:22])=[C:16]([C:17]([C:18]([O:20][CH3:21])=[O:19])=[CH:27][O:29][CH3:30])[N:11]3[N:10]=2)=[CH:5][CH:4]=1

Participants

6

Reactant 4

HCID 962WaterHCID 7865Methyl formateHCID 19701696HCID 19701696, compoundHCID 86752044HCID 86752044, compound

Product 1

HCID 67661237HCID 67661237, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A solution of 10 g of 2-(4-methoxyphenyl)-5-methoxycarbonylmethyl-6-methylimidazolo-[2,1-b]-1,3,4-thiadiazole in 50 cm3 of methyl formate is dripped into a solution of 1.8 g of sodium hydride bromide in 10 cm3 of anhydrous dimethylformamide (DMF). The solution is left under agitation overnight at ambient temperature and is then poured into water and extracted twice with ethyl acetate.

Workup

  1. extractionextracted twice with ethyl acetate

Sources & evidence

ORD record
ord-c7beb16be92547e492c399c556d4cf47
Source dataset
uspto-grants-1998_02
Patent number
US05716974

Reaction notes

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