反应详情

温度

65 °C

A mixture of 1-bromo-2-hydroxy-4-methoxy benzene (68.3 g, 0.336 moles), anhydrous potassium carbonate (51.2 g 0.37 moles) and 0.5L of N,N-dimethylformamide was heated to 65° C. Benzyloxyethylbromide (76.0 g, 0.353 moles) was added dropwise over 0.5 hr. After stirring for 1.5 hr. at 65° C., the reaction mixture was cooled and filtered. The filtrate was diluted with 1L of deionized water, and extracted with 3×0.5L ethyl acetate. The organic extracts were washed with brine, dried over MgSO4, and concentrated in vacuo. Distillation gave 93 g (83%) of product as a yellow liquid (b.p. 170°-175° C., 0.5 mm).

1. temperatureat 65° C., the reaction mixture was cooled
2. filtrationfiltered
3. additionThe filtrate was diluted with 1L of deionized water
4. extractionextracted with 3×0.5L ethyl acetate
5. washThe organic extracts were washed with brine
6. dry with materialdried over MgSO4
7. concentrationconcentrated in vacuo
8. distillationDistillation