反应详情

A mixture of 2-(5-bromo-α-cyano-2-methoxymethoxybenzyl)-3-methoxymethoxypyridine (2.40 g), potassium carbonate (2.53 g), tetrabutylammonium hydrogensulfate (0.41 g) and DMF (24 ml) was stirred for 38 hours at room temperature. The reaction mixture was poured into water, which was subjected to extraction with ethyl acetate. The extract solution was washed with water, dried (anhydrous sodium sulfate), and concentrated to leave an oily product. The oily product was purified by means of a silica gel column chromatography (eluted with ethyl acetate/hexane) to give 2-(5-bromo-2-methoxymethoxybenzoyl)-3-methoxymethoxypyridine (2.03 g) as an oily product, whose spectrum data are shown below.

1. extractionwas subjected to extraction with ethyl acetate
2. washThe extract solution was washed with water
3. dry with materialdried (anhydrous sodium sulfate)
4. concentrationconcentrated
5. customto leave an oily product
6. customThe oily product was purified by means of a silica gel column chromatography (eluted with ethyl acetate/hexane)