HCID 19701557, compound → HCID 19701629, compound

HRID 862088Notes

Reaction equation

HRID 862088 reaction equation
CS(C)=O.[OH2:5].[Br:6][C:7]1[C:8]([F:34])=[CH:9][C:10]([O:30][CH2:31][O:32][CH3:33])=[C:11]([CH:29]=1)[CH:12]([C:15]1[C:20]([O:21][CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)=[CH:19][CH:18]=[CH:17][N:16]=1)C#N>CN(C=O)C>[Br:6][C:7]1[C:8]([F:34])=[CH:9][C:10]([O:30][CH2:31][O:32][CH3:33])=[C:11]([CH:29]=1)[C:12]([C:15]1[C:20]([O:21][CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)=[CH:19][CH:18]=[CH:17][N:16]=1)=[O:5]

Participants

4

Reactant 2

HCID 19701557HCID 19701557, compoundHCID 23503278(Methanesulfinyl)methane--water (1/1)

Product 1

HCID 19701629HCID 19701629, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

By using DMSO/water (10:1), in place of DMF in Reference Example 40, 2-(5-bromo-α-cyano-4-fluoro-2-methoxymethoxybenzyl)-3-benzyloxypyridine (2.53 g) was subjected to oxidative decyanation to afford 2-(5-bromo-4-fluoro-2-methoxymethoxybenzoyl)-3-benzyloxypyridine (2.46 g) (Compound F-9). Physico-chemical properties and spectrum data are shown in Table 22 and Table 23.

Sources & evidence

ORD record
ord-a714cf2537784b9f8579e66b99f8d7a8
Source dataset
uspto-grants-1998_02
Patent number
US05716971

Reaction notes

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