epsilon-CAPROLACTONE → Poliglecaprone
Reaction equation
[CH2:1]1[O:8][C:6](=[O:7])[CH2:5][O:4][C:2]1=[O:3].[C:9]1(=[O:16])[O:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1>>[CH2:1]1[O:8][C:6](=[O:7])[CH2:5][O:4][C:2]1=[O:3].[C:9]1(=[O:16])[O:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1Participants
Procedure
A suture made from a copolymer of glycolide and ε-caprolactone made by (a) extruding a melted copolymer of glycolide and ε-caprolactone resin through an orifice and rapidly quenching the melted copolymer resin to produce a filament; (b) drawing the filament in the range of from about 4× to about 7.5× in a first drawing zone, to produce a drawn filament; (c) drawing the drawn filament in a second drawing zone in the range of from about 1.0× to about 4× while in a first heated zone being maintained at a temperature in the range of from about 150° F. to about 450° F., to form a doubly drawn filament; (d) relaxing the doubly drawn filament in the range of from about 0.75× to about 0.98×, in a second heated zone being maintained at a temperature in the range of from about 100° F. to about 400° F., to form a relaxed filament; then rack annealing the relaxed filament at a temperature of from about 85° C. to about 125° C. for at least 4 to 8 hours to form a glycolide/ε-caprolactone suture.
Workup
- customrapidly quenching the melted copolymer resin
- customto produce a filament
- customto produce a drawn filament
- temperaturebeing maintained at a temperature in the range of from about 150° F. to about 450° F.
- customto form a doubly drawn filament
- temperaturein a second heated zone being maintained at a temperature in the range of from about 100° F. to about 400° F.
- customto form a relaxed filament
Sources & evidence
- ORD record
- ord-9de66c52140c4ba9b33077061ca0ceaf
- Source dataset
- uspto-grants-1998_02
- Patent number
- US05718716
Reaction notes
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