反应详情

N-(6-hydroxyhexyl)-N-methylaniline 2 was prepared by mixing N-methylaniline (153 g, 1.43 mol.), 6-chlorohexanol (200 g, 1.46 mol.), potassium carbonate (200 g, 1.45 mol.) and potassium iodide (6 g, catalyst) in 750 mL of n-butanol. The mixture was heated to reflux under argon with vigorous external stirring for 96 hours. The solution was cooled, filtered, and the solvent was removed in vacuo. The residue was distilled under high vacuum to yield 2 (235 g, 79.5% yield) as a colorless oil, having a boiling point of 120°-125° C. (0.05 mm Hg).

1. customN-(6-hydroxyhexyl)-N-methylaniline 2 was prepared
2. temperatureThe mixture was heated
3. temperatureto reflux under argon with vigorous
4. temperatureThe solution was cooled
5. filtrationfiltered
6. customthe solvent was removed in vacuo
7. distillationThe residue was distilled under high vacuum