Sodium Iodide → HCID 23287291, compound

HRID 862557Notes

Reaction equation

HRID 862557 reaction equation
[OH:1][C:2]1[C:3]2[N:4]([C:8]([CH3:12])=[C:9]([CH3:11])[N:10]=2)[CH:5]=[CH:6][CH:7]=1.Cl[CH2:14][C:15]1[C:20]([CH3:21])=[CH:19][CH:18]=[CH:17][C:16]=1[NH:22][C:23](=[O:29])[O:24][CH2:25][CH2:26][O:27][CH3:28].[I-].[Na+].C(=O)([O-])[O-].[Na+].[Na+]>CC(C)=O>[CH3:28][O:27][CH2:26][CH2:25][O:24][C:23]([NH:22][C:16]1[CH:17]=[CH:18][CH:19]=[C:20]([CH3:21])[C:15]=1[CH2:14][O:1][C:2]1[C:3]2[N:4]([C:8]([CH3:12])=[C:9]([CH3:11])[N:10]=2)[CH:5]=[CH:6][CH:7]=1)=[O:29]

Participants

6

Reactant 4

HCID 5238Sodium IodideHCID 10340Sodium CarbonateHCID 224679492,3-Dimethylimidazo[1,2-a]pyridin-8-olHCID 53835417HCID 53835417, compound

Product 1

HCID 23287291HCID 23287291, compoundYield 22.5%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Analogously to Example 5, 2.0 g (12.4 mmol) of 8-hydroxy-2,3-dimethylimidazo[1,2-a]pyridine, 3.6 g (13.9 mmol) of 2-methoxyethyl 2-chloromethyl-3-methylphenylcarbamate, 0.18 g of sodium iodide and 1.3 g of sodium carbonate are reacted in 30 ml of acetone. 1.07 g (22.5%) of the title compound of m.p. 107°-108° C. are obtained.

Sources & evidence

ORD record
ord-f7f1d8d83cd54a109265d4d6196f651a
Source dataset
uspto-grants-1998_02
Patent number
US05719161

Reaction notes

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