Hydrochloric Acid → HCID 131720485, compound

HRID 862589Notes

Reaction equation

HRID 862589 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[CH2:16][CH2:15][C@@H:14]([CH2:17][C:18](=[O:41])[NH:19][C:20]3[CH:25]=[CH:24][C:23]([CH2:26][NH:27]C(OC(C)(C)C)=O)=[CH:22][C:21]=3[CH2:35][CH2:36][CH2:37][C:38]([OH:40])=[O:39])[N:6]3[C:7](=[O:13])[C:8](=[O:12])[NH:9][C:10]([CH:11]=1)=[C:5]23.[ClH:42]>O1CCOCC1>[ClH:42].[Br:1][C:2]1[CH:3]=[C:4]2[CH2:16][CH2:15][C@@H:14]([CH2:17][C:18](=[O:41])[NH:19][C:20]3[CH:25]=[CH:24][C:23]([CH2:26][NH2:27])=[CH:22][C:21]=3[CH2:35][CH2:36][CH2:37][C:38]([OH:40])=[O:39])[N:6]3[C:7](=[O:13])[C:8](=[O:12])[NH:9][C:10]([CH:11]=1)=[C:5]23

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 131720487HCID 131720487, compound

Product 1

HCID 131720485HCID 131720485, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

To a solution of (S)-9-Bromo-5-[p-tert-butoxycarbonylaminomethyl-o-(3-carboxypropyl) phenylcarbamoylmethyl]-6,7-dihydro-1H, 5H-pyrido[1,2,3-de]quinoxaline-2,3-dione (103 mg, 0.164 mmol)in 1,4-dioxane (5 mL) was added 4N hydrogen chloride in 1,4-dioxane (5 mL) at room temperature. The mixture was stirred for 20 h at room temperature and concentrated. The residual solid was dried in vacuo to give 90 mg of the title compound (97%).

Workup

  1. concentrationconcentrated
  2. customThe residual solid was dried in vacuo

Sources & evidence

ORD record
ord-74baa80a09904868aade63bc7edf35e1
Source dataset
uspto-grants-1998_02
Patent number
US05719152

Reaction notes

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