Hydrochloric Acid → HCID 131720493, compound

HRID 862596Notes

Reaction equation

HRID 862596 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[CH2:16][CH2:15][C@@H:14]([CH2:17][C:18](=[O:42])[NH:19][C:20]3[CH:25]=[CH:24][C:23]([CH2:26][NH:27]C(OC(C)(C)C)=O)=[CH:22][C:21]=3[O:35][CH2:36][C:37]([O:39][CH2:40][CH3:41])=[O:38])[N:6]3[C:7](=[O:13])[C:8](=[O:12])[NH:9][C:10]([CH:11]=1)=[C:5]23.Cl>C(OCC)(=O)C.O1CCOCC1>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]2[CH2:16][CH2:15][C@@H:14]([CH2:17][C:18](=[O:42])[NH:19][C:20]3[CH:25]=[CH:24][C:23]([CH2:26][NH2:27])=[CH:22][C:21]=3[O:35][CH2:36][C:37]([O:39][CH2:40][CH3:41])=[O:38])[N:6]3[C:7](=[O:13])[C:8](=[O:12])[NH:9][C:10]([CH:11]=1)=[C:5]23

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 131720492HCID 131720492, compound

Product 1

HCID 131720493HCID 131720493, compoundYield 201.3%

Reagents, catalysts & solvents 2

HCID 8857Ethyl AcetateSolventHCID 312751,4-DioxaneSolvent

Procedure

A suspension of (S)-9-chloro-5-[p-tert-butoxycarbonylaminomethyl-o-(ethoxycarbonylmethoxy) phenylcarbamoylmethyl]-6,7-dihydro-1H, 5H-pyrido[1,2,3-de]quinoxaline-2,3-dione (150 mg) in ethyl acetate (4 mL) was added 4N hydrogen chloride in 1,4-dioxane (2 mL). The mixture was stirred for 3 h at room temperature, and concentrated in vacuo to give 135 mg of the title compound.

Workup

  1. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-a1dc1da7f8c0418f900935667bddf9cc
Source dataset
uspto-grants-1998_02
Patent number
US05719152

Reaction notes

Loading…