Methanesulfonic Acid → 1-Methyl-2-isopropylamino-5-methoxycarbonylpyrimidinium sulfate

HRID 862709Notes

Reaction equation

HRID 862709 reaction equation
C[S:2]([OH:5])(=[O:4])=[O:3].[OH-].[CH3:7][N+:8]1[CH:13]=[C:12]([C:14]([O:16][CH3:17])=[O:15])[CH:11]=[N:10][C:9]=1[NH:18][CH:19]([CH3:21])[CH3:20]>O1CCCC1>[S:2]([O-:5])([O-:15])(=[O:4])=[O:3].[CH3:7][N+:8]1[CH:13]=[C:12]([C:14]([O:16][CH3:17])=[O:15])[CH:11]=[N:10][C:9]=1[NH:18][CH:19]([CH3:21])[CH3:20].[CH3:7][N+:8]1[CH:13]=[C:12]([C:14]([O:16][CH3:17])=[O:15])[CH:11]=[N:10][C:9]=1[NH:18][CH:19]([CH3:21])[CH3:20]

Participants

4

Reactant 2

HCID 6395Methanesulfonic AcidHCID 196988161-Methyl-2-isopropylamino-5-methoxycarbonylpyrimidinium hydroxide

Product 1

HCID 676602951-Methyl-2-isopropylamino-5-methoxycarbonylpyrimidinium sulfate

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

1.09 mlg [sic] (16.78 mol; 1.61 g) of methane-sulfonic acid is added to a solution of 1-methyl-2-isopropylamino-5-methoxycarbonylpyrimidinium hydroxide (3.48 g; 15.35 mol) dissolved in 100 ml of anhydrous tetrahydrofuran. The mixture is stirred under argon at room temperature for one hour. The precipitate which forms is filtered and then rinsed with ether.

Workup

  1. filtrationThe precipitate which forms is filtered
  2. washrinsed with ether

Sources & evidence

ORD record
ord-81d2d451e6dc4b3a8b7b808965465d1a
Source dataset
uspto-grants-1998_02
Patent number
US05719187

Reaction notes

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