Methanesulfonic Acid → HCID 67660277, compound

HRID 862712Notes

Reaction equation

HRID 862712 reaction equation
[OH-:1].[CH3:2][N+:3]1[CH:8]=[C:7]([C:9]([O:11][CH3:12])=[O:10])[CH:6]=[N:5][C:4]=1[NH:13][CH2:14][C:15]1[CH:24]=[CH:23][C:20]([O:21][CH3:22])=[C:17]([O:18][CH3:19])[CH:16]=1.C[S:26]([OH:29])(=[O:28])=[O:27]>O1CCCC1>[S:26]([O-:29])([O-:1])(=[O:28])=[O:27].[CH3:2][N+:3]1[CH:8]=[C:7]([C:9]([O:11][CH3:12])=[O:10])[CH:6]=[N:5][C:4]=1[NH:13][CH2:14][C:15]1[CH:24]=[CH:23][C:20]([O:21][CH3:22])=[C:17]([O:18][CH3:19])[CH:16]=1.[CH3:2][N+:3]1[CH:8]=[C:7]([C:9]([O:11][CH3:12])=[O:10])[CH:6]=[N:5][C:4]=1[NH:13][CH2:14][C:15]1[CH:24]=[CH:23][C:20]([O:21][CH3:22])=[C:17]([O:18][CH3:19])[CH:16]=1

Participants

4

Reactant 2

HCID 6395Methanesulfonic AcidHCID 19698828HCID 19698828, compound

Product 1

HCID 67660277HCID 67660277, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To 400 mg of 1-methyl-2-veratrylamino-5-methoxycarbonylpyrimidinium hydroxide dissolved in 15 ml of anhydrous tetrahydrofuran, are added 85 μl (1.1 eq; 1.31 mmol) of methanesulfonic acid. The mixture is stirred under argon at room temperature for one hour. The precipitate is filtered, rinsed with tetrahydrofuran and ether and then dried (weight: 490 mg - yield: 96%).

Workup

  1. filtrationThe precipitate is filtered
  2. washrinsed with tetrahydrofuran and ether
  3. customdried (weight: 490 mg - yield: 96%)

Sources & evidence

ORD record
ord-ff9104b2730a4de0ac748fda3c962bd7
Source dataset
uspto-grants-1998_02
Patent number
US05719187

Reaction notes

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