反应详情

A solution of 2-chloro-5-nitrophenol (114 g, 0.66 mol) in ethyl acetate (500 mL) was treated with 5% Pt/C (510 mg, 0.5 weight %) and the mixture shaken under a hydrogen atmosphere (30 psi) for 6 h. The mixture was filtered through Celite® and the residue washed well with ethyl acetate. Evaporation of the ethyl acetate gave a solid (95 g, 100% crude yield) which was taken directly into the next step.

1. filtrationThe mixture was filtered through Celite®
2. washthe residue washed well with ethyl acetate
3. customEvaporation of the ethyl acetate
4. customgave a solid (95 g, 100% crude yield) which