HCID 19697711, compound → HCID 19697826, compound

HRID 863223Notes

Reaction equation

HRID 863223 reaction equation
C([N:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH2:11][CH:10]([C:18](=[O:20])[CH3:19])[CH2:9]1)C1C=CC=CC=1>O1CCCC1.[Pd]>[C:18]([CH:10]1[CH2:11][C:12]2[C:17](=[CH:16][CH:15]=[CH:14][CH:13]=2)[NH:8][CH2:9]1)(=[O:20])[CH3:19]

Participants

4

Reactant 1

HCID 19697711HCID 19697711, compound

Product 1

HCID 19697826HCID 19697826, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

868 mg of 1-benzyl-3(R,S)-acetyl-1,2,3,4-tetrahydroquinoline are hydrogenated to saturation in 100 ml of tetrahydrofuran in the presence of 100 mg of palladium-on-charcoal (10% of Pd) under normal pressure at room temperature. The reaction mixture is filtered and the concentrated filtrate is purified by means of FC over 50 g of silica gel (mobile phase B). This gives the title compound: Rf (A)=0.29; Rf (D)=0.08.

Workup

  1. filtrationThe reaction mixture is filtered
  2. customthe concentrated filtrate is purified by means of FC over 50 g of silica gel (mobile phase B)

Sources & evidence

ORD record
ord-ec3cfafaa88242788d86a8e9507b65e3
Source dataset
uspto-grants-1998_02
Patent number
US05719141

Reaction notes

Loading…