HRID863235

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6495

2,2-Dimethoxypropane

C5H12O2

HCID521998

4-Methylbenzenesulfonic acid hydrate

C7H10O4S

结构：C=CC(C[C@H](O)[C@H](CC(C)(C)CCO[Si](C(C)C)(C(C)C)C(C)C)NC(=O)OC(C)(C)C)C(C)C

HCID22882581

未命名化合物

PRODUCTS

生成物

结构：C=CC(C[C@@H]1OC(C)(C)N(C(=O)OC(C)(C)C)[C@H]1CC(C)(C)CCO[Si](C(C)C)(C(C)C)C(C)C)C(C)C

HCID131720512

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

4.4 g of 6(S)-tert-butoxycarbonylamino-8,8-dimethyl-5(S)-hydroxy-3(R,S)-isopropyl-10-triisopropylsilyloxydec-1-ene and 134 mg of p-toluenesulfonic acid hydrate are stirred in 25 ml of methylene chloride and dimethoxypropane at room temperature for 2 h. After the reaction mixture has been concentrated, the residue is purified over 500 g of silica gel by means of FC (mobile phase D): Rf (D)=0.61.

WORKUP

后处理

concentrationAfter the reaction mixture has been concentrated
customthe residue is purified over 500 g of silica gel by means of FC (mobile phase D)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-eb4bbf64872147c6b1284cdbcd8d3cc3
来源数据集: uspto-grants-1998_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05719141
来源说明: uspto-grants-1998_02

反应 SMILES

[C:1]([O:5][C:6]([NH:8][C@@H:9]([CH2:19][C:20]([CH3:35])([CH3:34])[CH2:21][CH2:22][O:23][Si:24]([CH:31]([CH3:33])[CH3:32])([CH:28]([CH3:30])[CH3:29])[CH:25]([CH3:27])[CH3:26])[C@@H:10]([OH:18])[CH2:11][CH:12]([CH:15]([CH3:17])[CH3:16])[CH:13]=[CH2:14])=[O:7])([CH3:4])([CH3:3])[CH3:2].O.[C:37]1(C)[CH:42]=CC(S(O)(=O)=O)=C[CH:38]=1.COC(OC)(C)C>C(Cl)Cl>[C:1]([O:5][C:6]([N:8]1[C@@H:9]([CH2:19][C:20]([CH3:34])([CH3:35])[CH2:21][CH2:22][O:23][Si:24]([CH:25]([CH3:26])[CH3:27])([CH:28]([CH3:30])[CH3:29])[CH:31]([CH3:33])[CH3:32])[C@H:10]([CH2:11][CH:12]([CH:15]([CH3:17])[CH3:16])[CH:13]=[CH2:14])[O:18][C:37]1([CH3:42])[CH3:38])=[O:7])([CH3:4])([CH3:2])[CH3:3]