Iodoacetamide → HCID 19697808, compound

HRID 863250Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([N+:10]([O-:12])=[O:11])=[C:7]([OH:9])[CH:8]=1.C(=O)([O-])[O-].[K+].[K+].I[CH2:20][C:21]([NH2:23])=[O:22]>>[C:21]([CH2:20][O:9][C:7]1[CH:8]=[C:3]([O:2][CH3:1])[CH:4]=[CH:5][C:6]=1[N+:10]([O-:12])=[O:11])(=[O:22])[NH2:23]

Participants

Reactant 3

HCID 3727Iodoacetamide

HCID 11430Potassium Carbonate

HCID 2196355-Methoxy-2-nitrophenol

Product 1

HCID 19697808HCID 19697808, compound

Procedure

Reaction of 0.84 g of 5-methoxy-2-nitrophenol, 1.66 g of potassium carbonate and 1.84 g of iodoacetamide by the process described in Example 55) gives 2-carbamoylmethoxy-4-methoxynitrobenzene: mp 185°-7° C.; Rf (O)=0.58.

Sources & evidence

ORD record: ord-0ab715f689ca4090aecbbb8978881e6d
Source dataset: uspto-grants-1998_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05719141

Reaction notes

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