Iodoacetamide → HCID 19697735, compound

HRID 863254Notes

Reaction equation

[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[C:7]([N+:12]([O-:14])=[O:13])[CH:6]=1)=[O:4].C(=O)([O-])[O-].[K+].[K+].I[CH2:22][C:23]([NH2:25])=[O:24]>>[C:23]([CH2:22][O:11][C:8]1[CH:9]=[CH:10][C:5]([C:3]([O:2][CH3:1])=[O:4])=[CH:6][C:7]=1[N+:12]([O-:14])=[O:13])(=[O:24])[NH2:25]

Participants

Reactant 3

HCID 3727Iodoacetamide

HCID 11430Potassium Carbonate

HCID 66835Benzoic acid, 4-hydroxy-3-nitro-, methyl ester

Product 1

HCID 19697735HCID 19697735, compound

Procedure

is obtained analogously to Example 55) starting from 3.66 g of 4-methoxycarbonyl-2-nitrophenol, 6.91 g of potassium carbonate and 4.62 g of iodoacetamide: mp 185°-7° C.; Rf (O)=0.56.

Workup

customis obtained analogously to Example 55)

Sources & evidence

ORD record: ord-d756f0c860a64856adaa515958970698
Source dataset: uspto-grants-1998_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05719141

Reaction notes

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