Hydrochloric Acid → HCID 19696143, compound

HRID 863482Notes

Reaction equation

HRID 863482 reaction equation
C([NH:4][C:5]1[C:6]([N+:20]([O-:22])=[O:21])=[CH:7][C:8]([Br:19])=[C:9]2[C:14]=1[CH2:13][CH:12]([O:15]C(=O)C)[CH2:11][CH2:10]2)(=O)C.Cl>C(O)(=O)C>[NH2:4][C:5]1[C:6]([N+:20]([O-:22])=[O:21])=[CH:7][C:8]([Br:19])=[C:9]2[C:14]=1[CH2:13][CH:12]([OH:15])[CH2:11][CH2:10]2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 54148592HCID 54148592, compound

Product 1

HCID 19696143HCID 19696143, compoundYield 103.2%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
90 °C

Procedure

A mixture of acetic acid 8-acetylamino-5-bromo-7-nitro-1,2,3,4-tetrahydronaphthalen-2-yl ester (2 g, 5.4 mmol), acetic acid (15 mL) and 6N HCl (30 mL) was stirred at 90° C. for 18 h. The solvent was removed by rotoevaporation to give the product (1.6 g) as an orange solid in quantitative yield.

Workup

  1. customThe solvent was removed by rotoevaporation

Sources & evidence

ORD record
ord-10602da88ced42069c5f5e0b2ab4d1dc
Source dataset
uspto-grants-1998_02
Patent number
US05721234

Reaction notes

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