Hydrochloric Acid → HCID 19696169, compound

HRID 863495Notes

Reaction equation

HRID 863495 reaction equation
C([NH:4][C:5]1[C:6]([N+:19]([O-:21])=[O:20])=[C:7]2[C:11](=[CH:12][C:13]=1[Br:14])[CH2:10][CH:9]([NH:15]C(=O)C)[CH2:8]2)(=O)C.[ClH:22]>>[ClH:22].[Br:14][C:13]1[CH:12]=[C:11]2[C:7]([CH2:8][CH:9]([NH2:15])[CH2:10]2)=[C:6]([N+:19]([O-:21])=[O:20])[C:5]=1[NH2:4]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 19696172HCID 19696172, compound

Product 1

HCID 19696169HCID 19696169, compoundYield 93%

Procedure

N-(5-Acetylamino-6-bromo-4-nitro-indan-2-yl)-acetamide (1 g, 2.8 mmol) was stirred in 3N HCl (80 mL) at reflux for 3 h. The resulting solid was collected by filtration and dried in vacuo. Additional material was obtained by evaporation of the filtrate to give a combined yield of 93% of the yellow orange product (0.8 g).

Workup

  1. temperatureat reflux for 3 h
  2. filtrationThe resulting solid was collected by filtration
  3. customdried in vacuo
  4. customAdditional material was obtained by evaporation of the filtrate

Sources & evidence

ORD record
ord-6294c85ff2084528a20f325baabf4fce
Source dataset
uspto-grants-1998_02
Patent number
US05721234

Reaction notes

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