Acetic Acid → HCID 19696199, compound

HRID 863518Notes

Reaction equation

HRID 863518 reaction equation
C([NH:4][C:5]1[C:6]([N+:20]([O-:22])=[O:21])=[C:7]2[C:11](=[CH:12][C:13]=1[Br:14])[CH:10](CCC(O)=O)[CH2:9][CH2:8]2)(=O)C.[C:23]([OH:26])(=[O:25])C>Cl>[NH2:4][C:5]1[C:6]([N+:20]([O-:22])=[O:21])=[C:7]2[C:11](=[CH:12][C:13]=1[Br:14])[CH2:10][CH:9]([C:23]([OH:26])=[O:25])[CH2:8]2

Participants

4

Reactant 2

HCID 176Acetic AcidHCID 19696247HCID 19696247, compound

Product 1

HCID 19696199HCID 19696199, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of 5-acetamido-6-bromo-2-carboxyethyl-4-nitroindane (7.1 g, 19 mmol) in acetic acid (25 mL) and 3N HCl (100 mL) was heated at 100° C. for 18 h. The mixture was concentrated by rotoevaporation, and the resulting orange solid was collected by filtration, washed with ether and dried to give the product (5.5 g).

Workup

  1. concentrationThe mixture was concentrated by rotoevaporation
  2. filtrationthe resulting orange solid was collected by filtration
  3. washwashed with ether
  4. customdried

Sources & evidence

ORD record
ord-25b840cacb644f12b1e059e1138fb8fa
Source dataset
uspto-grants-1998_02
Patent number
US05721234

Reaction notes

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