Methanesulfonic Acid → HCID 86752152, compound

HRID 863587Notes

Reaction equation

HRID 863587 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([S:9]([CH3:12])(=[O:11])=[O:10])=[CH:5][C:4]=1[CH2:13][NH:14][C@H:15]1[CH:20]2[CH2:21][CH2:22][N:17]([CH2:18][CH2:19]2)[C@H:16]1[CH:23]([C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1.[CH3:36][S:37]([OH:40])(=[O:39])=[O:38]>CC(C)=O>[S:37]([OH:40])(=[O:39])(=[O:38])[CH3:36].[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([S:9]([CH3:12])(=[O:11])=[O:10])=[CH:5][C:4]=1[CH2:13][NH:14][C@H:15]1[CH:20]2[CH2:19][CH2:18][N:17]([CH2:22][CH2:21]2)[C@H:16]1[CH:23]([C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)[C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1

Participants

4

Reactant 2

HCID 6395Methanesulfonic AcidHCID 53856125HCID 53856125, compound

Product 1

HCID 86752152HCID 86752152, compoundYield 90.6%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

To a solution of (2S,3S)-N-(2-methoxy-5-methylsulfonylphenyl)methyl-2-diphenylmethyl-1-azabicyclo[2.2.2]octan-3-amine (400 mg, 0.82 mmol) in acetone (10 mL) was added methanesulfonic acid (0.41 mmol, 39.2 mg). The precipitated white solid was filtered off to give the title compound (218 mg, 30.3%, 1st crop).

Workup

  1. filtrationThe precipitated white solid was filtered off

Sources & evidence

ORD record
ord-dc1de828b900414b9045f77505d1865d
Source dataset
uspto-grants-1998_02
Patent number
US05721255

Reaction notes

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