HCID 54678585, compound → 7,8-Dihydropyrido[1,2-a]indol-9(6H)-one

HRID 863677Notes

Reaction equation

HRID 863677 reaction equation
[OH:1][C:2]1[C:7]2=[CH:8][C:9]3[C:14]([N:6]2[CH2:5][CH2:4][C:3]=1C(OCC)=O)=[CH:13][CH:12]=[CH:11][CH:10]=3>C(O)C.O.Cl>[CH:10]1[CH:11]=[CH:12][CH:13]=[C:14]2[C:9]=1[CH:8]=[C:7]1[C:2](=[O:1])[CH2:3][CH2:4][CH2:5][N:6]12

Participants

5

Reactant 1

HCID 54678585HCID 54678585, compound

Product 1

HCID 150633937,8-Dihydropyrido[1,2-a]indol-9(6H)-oneYield 99.8%

Reagents, catalysts & solvents 3

HCID 313Hydrochloric AcidSolventHCID 702EthanolSolventHCID 962WaterSolvent

Procedure

A solution of 1.03 g of ethyl 6,7-dihydro-9-hydroxypyrido[1,2-a]indole-8-carboxylate in 20 ml of ethanol, 10 ml of water and 10 ml of concentrated hydrochloric acid was heated at 80° C. for 3 hours. The solvents were evaporated to give 740 mg of 7,8-dihydropyrido[1,2-a]indol-9(6H)-one of melting point 138°-140° C.

Workup

  1. customThe solvents were evaporated

Sources & evidence

ORD record
ord-acefca05672f4d9689d62e9a41cede22
Source dataset
uspto-grants-1998_02
Patent number
US05721245

Reaction notes

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